Xuzhou City is located at the border of the four provinces of Jiangsu, Shandong, Henan and Anhui, and is an important transportation hub in East China. Its expressway construction has the typical characteristics such as frequent three-reconstruction projects, scattered relocation objects, complex cross-domain constraints and long construction organization chains, which puts forward higher requirements for design and construction management. Based on the above regional characteristics, the application value of BIM technology in the design and construction stages of expressways in Xuzhou is analyzed. Research shows that BIM significantly optimizes the alignment scheme under the complex terrain condition and improves the safety of highway construction through the three-dimensional line-of-sight review and collaborative design. Through the modeling verification of the three-reconstruction projects and land acquisition and relocation management, the rationality and social coordination of the engineering scheme are strengthened. Based on the construction period management platform of BIM, the visualization and traceability of progress, quality and measurement are realized, which promotes the refinement and transparency of project management. The research results have verified the comprehensive benefits of BIM technology in dealing with the complex engineering characteristics of expressways in Xuzhou City, providing a technical path and value reference for similar projects in the region.