The vibrating screen of asphalt concrete mixing plant is an equipment for screening various aggregates, and the reasonable configuration of the vibrating screen aperture of asphalt concrete is the key to ensure the engineering quality and production efficiency. By analyzing the cases, the production mix proportion and the vibrating screen aperture of AC-25 asphalt concrete are studied. The screening capacity of the screen mesh is calculated and optimized according to the production efficiency of asphalt mixing plant. The configuration method of the vibrating screen aperture of the hot bin in the asphalt mixing plant is summarized and determined, and the phenomena of material overflow and waiting in the asphalt mixing plant are reduced, which maximizes the production efficiency of the asphalt mixing plant, and also makes the mix proportion of asphalt concrete more precise. The void ratio of mineral materials is reduced. And the indexes of pavement performance such as high-temperature resistance, splitting tensile strength and freeze-thaw splitting residual strength are further improved, which has practicability in the construction of asphalt pavement.