Focusing on the crack resistance of combined girder bridge decks in high-speed railway cable-stayed bridges, the research is conducted. The combined girder cable-stayed bridge is extensively utilized in long-span railway bridges due to its distinctive advantages. However, the crack resistance of bridge decks has consistently been a focal point in the engineering community. The complex stress of the bridge deck is susceptible to tensile stress, which can induce cracking and impact the durability of the bridge and the safe operation of high-speed railways. Taking the Yinghe Extra-large Bridge as the engineering context, the stress conditions of its bridge deck are analyzed and the applicability of various crack-resistant measures is discussed. The findings indicate that the rational configuration of prestressing is the most effective method for controlling the stress of the bridge deck. The fulcrum drop-beam method has an insignificant effect on improving the stress of the bridge deck. The participated stress of weighted concrete at the fulcrum can improve the stress of steel girders, but the thickness of the participated stress needs to be reasonably controlled. The activation stage of the double-combined weighted concrete at the fulcrum has an impact on the forces of both the bridge deck and the steel girder. The weights after the closure are relatively reasonable. These conclusions provide a scientific basis for the design, construction, and maintenance of high-speed railway cable-stayed bridges.