Taking the Shenshan Road Reconstruction Project as the research object, the influence of subway structural constraints on the road interchange scheme when the urban road and subway are parallel are deeply analyzed. A differentiated design strategy is proposed that for the over-crossing bridge scheme, the plane position relationship between the bridge pile foundation and the subway structure be mainly controlled to ensure a minimum lateral safety clearance of 3 m. For the under-crossing frame scheme, the vertical spatial coordination problem is emphatically solved, and the sufficient municipal pipeline space is reserved. In view of the spatial intersection of interchange and subway structure, it is necessary to consider the key parameters such as traffic function, landscape effect, engineering feasibility and economic benefit. The research results provide a systematic technical reference for the parallel design of roads and subways in complex urban environments.