Urban expressways are the crucial infrastructure for easing the urban traffic pressure. Yuedong Road Expressway occupies a pivotal position in the “six-horizontal eight-vertical” intelligent expressway transportation network of Shaoxing City, which is not only an important channel connecting the urban area and the expressway network, but also a vital support for promoting the north-south development of the city. The rational layout of interchanges and ramps is essential for maximizing the traffic benefits. On the basis of existing regulatory requirements, it is proposed that the layout of interchanges and ramps should comprehensively consider the planning, road network coordination, spacing, location and form. Taking the Shaoxing Yuedong Road Smart Expressway Project as an example, a comprehensive argument is conducted from the aspects of traffic function, road network structure, engineering construction conditions and so on to form a reasonable ramp layout scheme.