Municipal water supply and drainage pipeline engineering is usually located in the city center or surrounding areas. The factors of soil layer, geology and traditional construction method have the large impact on the surrounding road environment. The use of trenchless pipe jacking technology can more intuitively and effectively select the best scheme to solve the adverse impact of road settlement on the surrounding environment. Taking the relocation project of the inlet pipeline of Shanghai Nanqiao Sewage Pumping Station as the background, a three-dimensional model is established through ABAQUS finite element software to simulate and visually analyze the settlement law of soil layer under the different working conditions, soil types and jacking pipe diameter of the trenchless pipe-jacking construction. The reasonable pipe-jacking construction measures are proposed to decrease the influence on the differential road settlement, which lays the foundation for the promotion and application of pipe-jacking technology in the municipal water supply and drainage engineering in Fengxian District, Shanghai.