Due to the restriction of road alignment and channel direction, there is often the problem of overly large cross angle of bridges spanning channel in municipal engineering. For the oblique bridge with large deflection angle, the closed frame structure is usually adopted in practical engineering. Some bridges need to adopt composite foundation treatment due to the low bearing capacity of the base. When the pipe networks under the bridge are dense, there is no condition for laying the composite foundation piles, and it is impossible to use the large-area slab foundation. In view of the above unfavorable construction conditions, a cross-braced frame bridge scheme is proposed. The bored pile is used for the foundation, and the foundation pile is flexibly arranged according to the distribution of underground pipeline network. A cross brace is set at the top of the foundation pile to increase the horizontal support of the pile top. Compared to the double-row pile linear abutment, the cross-bracing beams offer better economic efficiency with a shorter construction time. The top of the foundation pile bears bending moments, and the stress acting on it is relatively complex. A stiffening beam is arranged on the free side of the roof end to improve the stress condition of the bridge deck slab. Combined with the engineering cases, the key design contents of cross-braced frame bridge with large deflection angle are analyzed and studied, and the relevant results can provide reference for similar construction projects.