The project of pumping station can be divided into two categories of water diversion and drainage. Some pumping station projects in the plain polder require the multiple operating conditions and scheduling functions such as pumping drainage, pumping diversion, automatic drainage and automatic diversion. Compared with the traditional pumping stations, this kind of pumping station has the advantages of saving investment, decreasing land and centralized management. The design essentials and difficulties of the diversion and drainage combined pumping station are the selection of overall layout and the determination of operating scheduling scheme. Combined with a water system connection project in Fuyang City, several overall layout schemes of the diversion and drainage combined pumping station with the multi-operating conditions are introduced and analyzed. The design schemes are all reasonable and feasible, which can provide the ideas and references for the design of other related pumping stations.