Abstract: Sewage sludge Co-incineration in coal power plants is still the mainstream technology for a long time in the future. Taking the sewage sludge co-incineration after drying in Yangzhou as an example, based on the key technical issues analysis of sewage sludge full drying and co-incineration in coal power plants for power generation, such as sludge solids content control, mixing combustion conditions, pollution control in power plants and sludge drying plants, this paper gives a brief introduction on the key process parameters and technical points analysis. The problem of sewage, odor, parts corrosion in flue-duct and flue gas treatment should be paid more attention to the project of sludge drying plants in combination with coal power plants. The control of sewage and odor pollutants in sludge drying plants should be paid more attention in such projects. It is necessary to continuously improve the technical level and implementation standard in combination with engineering pratice, so as to meet the goal of circular economy and CO2 neutrality in the development of the industry.