In recent years, with the promotion and development of national green, high quality and innovative concept, the proportion of prefabricated assembly technology in the construction of comprehensive pipe gallery is increasing year by year, which overcomes many deficiencies in the construction and operation of the comprehensive pipe gallery under the pouring site. As an underground project, reliable waterproof measures have always been the core of people's concern, and as a prefabricated assembled pipe gallery with more joints and joints, its waterproof problem is more prominent. This article through to assemble in different mode of rectangular, circular, pear-shaped prestressed assembly comprehensive utility tunnel waterproof technology is analyzed and discussed, explores the modular pipe gallery a variety of waterproof measures of the joint and deformation, focuses on the pipe rack combination structure form, waterproof technology, waterproof material and waterproof performance, the conclusion put forward reasonable effective waterproof technology, and analyze its economic benefits. The research results can improve the waterproof performance of precast pipe gallery to a certain extent, which is expected to be popularized in similar engineering applications such as modular precast pipe gallery and subway segment assembly.