Based on actual operating experience of the domestic sludge drying and incineration project, combined with the characteristics of sewage sludge in Qingpu District, Shanghai, the optimization of operation safety and stability, economic rationality, environmental friendliness and other urgent problems to be solved was proposed. The general layout, sludge transportation, sludge drying equipment selection, flue gas purification process, and comprehensive control of odorous gas, were optimized, considering the rationality of production organization and logistics personnel traffic, and environmental governance controllability, coordination of short- and long-term project operation and construction, reliability of sludge transportation, operation stability of drying equipment and convenience for maintenance, advanced flue gas purification technology, comprehensive odor control and treatment, etc..