Gannan expressway is the most important component of the expressway network system in the central urban area of Ganzhou city. Through the analysis of its function orientation, the design standard and overall scheme of expressway are defined. Considering with the planning conditions, construction conditions and landscape requirements along the road, the expressway laying form is determined in sections. The key nodes such as interchange, high-speed railway node and highway node are studied, and the evaluation of traffic organization shows that the scheme has good adaptability.