The Qilu Yellow River Bridge is one of the "three-bridge and one-tunnel" strategic channels for the "northward crossing-river" development of Jinan, which directly connects the south bank group and the Sangzidian regional center in the north bank. The construction of the project is of important meaning for Jinan to realize the northward crossing development for the construction of the Yellow River New District, and the construction of the pilot area of new and old kinetic energy conversion. Based on the construction conditions and constraints of the bridge location, the technical conditions, engineering cost, environmental influence and the other factors are comprehensively considered. The route scheme, highway-railway co-construction mode and crossing-river scheme of Qilu Yellow River Bridge are compared and designed. The relevant experience and conclusions can be used as references for related projects.