In order to rationally evaluate the impact of potential landslide on the engineering safety of bridge pile foundation in an expressway project, through the field survey, the human factors and natural factors affecting the engineering safety of bridge pile foundation in the gully area are put forward. These factors are the position of pile foundation, the waste earthwork and waste slag around pile foundation, the degree of construction specifications, the monitoring awareness, the protective measures, the rock-soil properties around pile, the relative height difference, the slope, the vegetation coverage, the maximum daily rainfall, the seismic intensity and the others. By further combined with the analytic hierarchy process, the fuzzy comprehensive analysis method, the expert scoring method, etc., the safety evaluation of the bridge pile foundation is carried out, and the safety degree of the supporting project is determined to be "Ⅱ", that is, the degree of danger is medium. The relevant conclusions can provide the targeted guidance for the supporting projects.