For the structure of super long-span self-anchored cable-stayed bridge, the main girder at the bridge pylon bears the huge axial force. The integral stability of the main girder becomes the key factor to control the structural stress. Five main factors of the height of main girder, the number of auxiliary piers, the constraint of pylon and beam, the height of pylon and the anchorage distance on the pylon which affect the integral stability of cable-stayed bridge structure are analyzed to determine the reasonable value of each parameter.