The topography of the plain areas is often covered with rivers and the elevation of the surrounding is lower. With the more and more strict approval of setting up the piers in water of objects crossing river by the water conservancy department, it is required to set up a large number of medium-span and long-span bridges. Due to this kind of bridge often required to level with the roads along a river, therefore, this kind of bridge has the characteristics of long span, strictly limited structural height and higher landscape demands of bridge structure. Combined with the design scheme of the structures across river in Yuyao City Taojia Road River Reconstruction Project, the single-span bridge design schemes of the medium and long spans are discussed, analyzed and compared, which can be referred for the scheme design of the similar bridges.